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- 產(chǎn)品名稱(chēng)： Recombinant Human MCU protein
- 產(chǎn)品貨號(hào)： CSP01762
- 貨期： 現(xiàn)貨
- 價(jià)格與訂購(gòu)： 1800
- 數(shù)量：
庫(kù)存： 100
- 規(guī)格： 50μg 100μg 1mg
- 產(chǎn)品信息
- 如何訂購(gòu)
概述（Summary）
英文全稱(chēng)
Recombinant Human MCU protein
純度（Purity）
>90% as determined by SDS-PAGE
內(nèi)毒素（Endotoxin level）
Please contact with the lab for this information.
蛋白構(gòu)建（Construction）
A DNA sequence encoding the human MCU (Val51-Thr233) was fused with His tag
Accession #
Q8NE86
表達(dá)宿主（Host）
E.coli
種屬（Species）
Homo sapiens (Human)
預(yù)測(cè)分子量（Predicted Molecular Mass）
21.77 kDa
制劑（Formulation）
Supplied as solution form in PBS pH 7.5 or lyophilized from PBS pH 7.5.
運(yùn)輸方式（Shipping）
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
穩(wěn)定性&儲(chǔ)存（Stability &Storage）
Use a manual defrost freezer and avoid repeated freeze thaw cycles.
Store at 2 to 8 °C for one week .
Store at -20 to -80 °C for twelve months from the date of receipt.
Store at 2 to 8 °C for one week .
Store at -20 to -80 °C for twelve months from the date of receipt.
復(fù)溶（Reconstitution）
Reconstitute in sterile water for a stock solution.A copy of datasheet will be provided with the products, please refer to it for details.
背景（Background）
背景介紹
Mitochondrial inner membrane calcium uniporter that mediates calcium uptake into mitochondria. Constitutes the pore-forming and calcium-conducting subunit of the uniporter complex (uniplex) Activity is regulated by MICU1 and MICU2. At low Ca2+ levels MCU activity is down-regulated by MICU1 and MICU2; at higher Ca2+ levels MICU1 increases MCU activity . Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways. Involved in buffering the amplitude of systolic calcium rises in cardiomyocytes. While dispensable for baseline homeostatic cardiac function, acts as a key regulator of short-term mitochondrial calcium loading underlying a 'fight-or-flight' response during acute stress: acts by mediating a rapid increase of mitochondrial calcium in pacemaker cells . participates in mitochondrial permeability transition during ischemia-reperfusion injury . Regulates glucose-dependent insulin secretion in pancreatic beta-cells by regulating mitochondrial calcium uptake . Mitochondrial calcium uptake in skeletal muscle cells is involved in muscle size in adults . Regulates synaptic vesicle endocytosis kinetics in central nerve terminal. Involved in antigen processing and presentation .
分子別名（Alternative Names）
Calcium uniporter protein, mitochondrial,HsMCU,Coiled-coil domain-containing protein 109A.
Note
For research use only .
地 址：
產(chǎn)品銷(xiāo)售：
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郵 編：
Amily
