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Recombinant Human SIRPA protein

>90% as determined by SDS-PAGE

Please contact with the lab for this information.

P78324

E.coli

Homo sapiens (Human)

Supplied as solution form in PBS pH 7.5 or lyophilized from PBS pH 7.5.

In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.

Use a manual defrost freezer and avoid repeated freeze thaw cycles.
Store at 2 to 8 °C for one week .
Store at -20 to -80 °C for twelve months from the date of receipt.

Reconstitute in sterile water for a stock solution.A copy of datasheet will be provided with the products, please refer to it for details.

Immunoglobulin-like cell surface receptor for CD47. Acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. Supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. May play a key role in intracellular signaling during synaptogenesis and in synaptic function. Involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin. Mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation. CD47 binding prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells.

Tyrosine-protein phosphatase non-receptor type substrate 1,Short name:SHP substrate 1,Short name:SHPS-1,Brain Ig-like molecule with tyrosine-based activation motifs,Short name:
Bit,CD172 antigen-like family member A,Inhibitory receptor SHPS-1,Macrophage fusion receptor,MyD-1 antigen,Signal-regulatory protein alpha-1,Short name:Sirp-alpha-1,Signal-regulatory protein alpha-2,Short name:Sirp-alpha-2,Signal-regulatory protein alpha-3,Short name:Sirp-alpha-3,p84,CD_antigen: CD172a

For research use only .