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產(chǎn)品概述（Summary）

產(chǎn)品名稱（Product name）

Recombinant SARS-CoV-2 (2019-nCoV) S Protein RBD

貨號（Catalog#）

CSMP02459COV

描述（description）

Recombinant SARS-CoV-2 S Protein RBD is produced by Mammalian cells expression system and the target gene encoding Thr333-Pro527 is expressed with C-His Tag

表達(dá)系統(tǒng)（Expression system）

Mammalian cells

種屬（Species）

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)

Accession #

YP_009724390.1

別名（Alternative names)

2019-nCov RBD Protein,2019-nCoV Spike RBD Protein

預(yù)測分子量（Predicted Molecular Mass）

23.66kDa

實(shí)際分子量（Actual Molecular Mass）

30kDa

純度（Purity）

>90% as determined by SDS-PAGE

內(nèi)毒素（Endotoxin level）

Please contact with the lab for this information

制劑（Formulation）

Supplied as solution form in PBS, pH7.5 or lyophilized from PBS, pH7.5

運(yùn)輸方式（Shipping）

In general, proteins are shipped out with blue ice unless customers require otherwise.

穩(wěn)定性&儲存（Stability &Storage）

Use a manual defrost freezer and avoid repeated freeze thaw cycles.
Store at 2 to 8 °C for one week .
Store at -20 to -80 °C for twelve months from the date of receipt.

復(fù)溶（Reconstitution）

Please refer to the instraction in the hard copy of COA.

應(yīng)用（Application）

Immunogen

背景（Background）

Protein S (PROS1) is glycoprotein and expressed in many cell types supporting its reported involvement in multiple biological processes that include coagulation, apoptosis, cancer development and progression, and the innate immune response. Known receptors bind S1 are ACE2, angiotensin-converting enzyme 2, DPP4, CEACAM etc.. The spike (S) glycoprotein of coronaviruses is known to be essential in the binding of the virus to the host cell at the advent of the infection process. Most notable is severe acute respiratory syndrome (SARS). The severe acute respiratory syndrome-coronavirus (SARS-CoV) spike (S) glycoprotein alone can mediate the membrane fusion required for virus entry and cell fusion. It is also a major immunogen and a target for entry inhibitors. It's been reported that 2019-nCoV can infect the human respiratory epithelial cells through interaction with the human ACE2 receptor. The spike protein is a large type I transmembrane protein containing two subunits, S1 and S2. S1 mainly contains a receptor binding domain (RBD), which is responsible for recognizing the cell surface receptor. S2 contains basic elements needed for the membrane fusion.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity.

Note

For research use only .