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- 產(chǎn)品名稱： Thailanstatin A
- 產(chǎn)品貨號(hào)： CS00002
- 貨期： 現(xiàn)貨
- 價(jià)格與訂購(gòu)： 1500
- 數(shù)量：
庫(kù)存： 10
- 規(guī)格： 10mg
- 產(chǎn)品信息
- 如何訂購(gòu)
產(chǎn)品描述
Thailanstatin A is an ultra-potent inhibitor of eukaryotic RNA splicing ( IC 50 =650 nM). Thailanstatin A exerts effects via non-covalent binding to the SF3b subunit of the U2 snRNA subcomplex of the spliceosome and shows low-nM to sub-nM IC 50 s against multiple cancer cell lines. Thailanstatin A, a payload for ADCs, is conjugated to the lysines on trastuzumab yielding “l(fā)inker-less” ADC [1] [2] [3] .
體外活性
Thailanstatin A (TST-A) is a potent antiproliferative natural product discovered by our group from Burkholderia thailandensis MSMB43 [2] . Thailanstatin A (DU-145, NCI-H232A, MDA-MB-231 and SKOV-3 cells) exhibits potent antiproliferative activities with GI 50 s in the single nM range (1.11-2.69 nM) [3] .
別名
泰蘭斯他汀A
分子量
535.63
分子式
C28H41NO9
CAS No.
1426953-21-0
存儲(chǔ)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
溶解度
DMSO: 245 mg/mL (457.41 mM), Need ultrasonic
( < 1 mg/ml refers to the product slightly soluble or insoluble )
參考文獻(xiàn)
1. Puthenveetil S, et al. Natural Product Splicing Inhibitors: A New Class of Antibody-Drug Conjugate (ADC) Payloads. Bioconjug Chem. 2016;27(8):1880-1888.
2. Ghosh AK, et al. Enantioselective Synthesis of Thailanstatin A Methyl Ester and Evaluation of in Vitro Splicing Inhibition. J Org Chem. 2018;83(9):5187-5198.
3. Liu X, et al. Genomics-guided discovery of thailanstatins A, B, and C As pre-mRNA splicing inhibitors and antiproliferative agents from Burkholderia thailandensis MSMB43. J Nat Prod. 2013;76(4):685-693.
Note
For research use only .
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